Clinical Intelligence/Clinical Efficiency

Clinical Intelligence Company Caribou Biosciences Adds New Member

Caribou Biosciences

Caribou Biosciences, Inc., a leading clinical-stage CRISPR genome-editing biopharmaceutical company, announced today that it has expanded its scientific advisory board (SAB) with the appointment of two new members: Katy Rezvani, M.D., Ph.D., professor of Stem Cell Transplantation and Cellular Therapy at The University of Texas MD Anderson Cancer Center; and Christopher Sturgeon, Ph.D., associate professor at the Icahn School of Medicine at Mount Sinai.

“As leaders in the study of natural killer (NK) cell biology, the development of NK cell therapies for the treatment of cancer, and the differentiation of induced pluripotent stem cells (iPSCs), Drs. Rezvani and Sturgeon will bring experience and insights that will be invaluable to Caribou as we develop genome-edited NK cell therapies derived from iPSCs using our proprietary next-generation chRDNA platform,” said Steven Kanner, Ph.D., Caribou’s chief scientific officer. “We are excited to welcome these renowned experts to our SAB and work with them as we advance our pipeline of potentially best-in-class genome-edited allogeneic CAR-T and CAR-NK cell therapies for cancer patient treatment.”

“The opportunity to carry out multiple high specificity genome edits with Caribou’s chRDNA platform in iPSCs followed by their differentiation into NK cells holds the promise of safer and more effective allogeneic cell therapies with broad therapeutic potential,” said Dr. Sturgeon. “I look forward to working with the Caribou team to help translate known iPSC and NK cell biology into effective therapies and potentially implement this therapeutic approach more widely for patients with solid tumors and metastases.”

Dr. Rezvani is the Sally Cooper Murray Chair in Cancer Research, chief of the Section for Cellular Therapy, director of Translational Research, and director of the GMP Facility at MD Anderson. She also serves as executive director of MD Anderson’s Adoptive Cell Therapy Platform. Her laboratory focuses on the role of NK cells in mediating immunity against hematologic and solid tumors in order to understand mechanisms of tumor-induced NK cell dysfunction and to develop strategies to genetically engineer NK cells to enhance their in vivo anti-tumor activity and persistence. Findings from Dr. Rezvani’s lab have led to the funding of several investigator-initiated clinical trials of NK cell immunotherapies in patients with hematologic malignancies and solid tumors, as well as the first-in-human clinical trial of off-the-shelf CAR-transduced cord blood-derived NK cells in patients with relapsed/refractory lymphoid malignancies. Dr. Rezvani completed her medical training at University College London, followed by fellowships from the Royal College of Physicians and the Royal College of Pathologists of the United Kingdom, a Ph.D. in Immunology from Imperial College London, and postdoctoral studies at the National Institutes of Health.

Dr. Sturgeon is an associate professor at the Icahn School of Medicine at Mount Sinai. His studies focus on characterizing the signal pathways that control human pluripotent stem cell differentiation towards hematopoietic stem/progenitors and how this impacts NK cell development and function. Prior to joining Mount Sinai, Dr. Sturgeon was a member of the Washington University School of Medicine Hematology Division. He received a Ph.D. in Biochemistry on cell cycle regulation at the University of British Columbia. Dr. Sturgeon completed postdoctoral studies at the McEwen Centre for Regenerative Medicine at the University of Toronto where he studied pluripotent stem cell-derived hematopoiesis.

Disclosures

Dr. Rezvani receives compensation as a member of Caribou’s SAB (as do the other SAB members), and this financial relationship has been disclosed to MD Anderson’s Conflict of Interest Committee in accordance with institutional policy.

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