Clinical Intelligence/Clinical Efficiency

Pentavere Partners Takeda to Support Evidence Analysis for Patients

  • Pentavere’s partnership with Takeda to pioneer real-world evidence analysis for HAE patients, addressing critical gaps in treatment understanding.
  • This innovative research collaboration has generated one of the largest cohort data sets globally of HAE with normal C1 inhibitor and will be utilized in enhancing patient outcomes through better understanding of current treatment use and clinical outcomes.
  • This partnership and commercial engagement builds upon Pentavere winning the Takeda Canada Innovation Challenge to accelerate rare disease diagnosis and care using new AI technology that was announced in May 2022.
  • The Canadian Organization of Rare Disorders celebrates this application of data science and analytics to patient data analysis and the public-private partnership as ground-breaking with potential to revolutionize diagnosis and care for all rare disease patients in Canada.
  • A manuscript and an abstract on this dataset are currently under preparation and being submitted for publication.

HEALWELL AI Inc. (“HEALWELL” or the “Company”) (TSX: AIDX) (OTCQX: HWAIF), an AI and data science company focused on preventative care, is proud to announce its subsidiary Pentavere Research Group (“Pentavere”) have engaged in a partnership and commercial engagement with Takeda Canada Inc. (“Takeda”) to drive real-world evidence analysis for rare diseases, particularly focusing on supporting patients suffering from hereditary angioedema (HAE) with normal C1 inhibitor across Canada. HAE with normal C1 inhibitor is an ultra-rare disease characterized by life-threatening recurrent, unpredictable swelling, and currently does not have any approved treatments.

The scarcity of real-world data on the prevalence and clinical outcomes of these patients poses a significant challenge to the development of novel therapeutic agents. Recognizing this critical unmet need, Takeda has collaborated with Pentavere and top HAE specialists across Canada to support research into the gaps in treatment guidelines and approved therapies for these patients. This innovative research collaboration has resulted in the generation of one of the largest cohort datasets globally of hereditary angioedema with normal C1 inhibitor patients.

Jefferson Tea, PhD, Vice President, Medical and Scientific Affairs, Takeda. “We are pleased to be partnering with Pentavere as this study is an ongoing example of our steadfast commitment to working with leading data science companies to drive innovation and assist patients in their care journey. By harnessing the power of AI and data analytics, and collaborating with experts in these fields, we aim to advance the understanding and management of rare diseases like HAE, supporting patients and their families in their care journey, and ultimately improving patient outcomes.”

Dr. Durhane Wong-Rieger CEO, of Canadian Organization for Rare Disorders stated, “When the number of patients is small, the use of AI and data analytics to understand the whole of their patient journey to inform diagnosis and best management is a game changer that could prove as impactful as decoding the human genome. We are extremely grateful to Pentavere, HEALWELL, and Takeda for investing in this initiative and for including CORD as a partner to drive to a vision where this is available for all patients.”

Aaron Leibtag, CEO of Pentavere, commented, “We are incredibly proud of our ongoing partnership with Takeda and how it has grown and evolved since winning the Takeda Canada Innovation Challenge to accelerate rare disease diagnosis and care. This collaboration not only underscores the significance of Pentavere’s technology, but also highlights the transformative impact data science can have in healthcare. Together, we are breaking new ground in real-world evidence analysis for rare diseases, reaffirming our commitment to driving innovation and improving patient outcomes.”

The comprehensive dataset compiled through this partnership will play a pivotal role in filling the real-world data gap on the burden of disease and clinical outcomes for HAE with normal C1 inhibitor patients. By leveraging advanced data science techniques, Pentavere analyzed this dataset as part of the PROSPECT study to extract actionable insights that can inform treatment strategies and improve patient outcomes. A manuscript and an abstract on the PROSPECT study data are currently under preparation and will be submitted for publication soon.

Pentavere unlocks a deeper understanding of patient treatment needs by enabling effortless data access and rapid insight generation. DARWEN™ has the capacity to harness electronic medical record data and utilizes advanced large language models to analyze disparate and siloed clinical notes that are otherwise very challenging to access, allowing meaningful solutions to some of healthcare’s biggest challenges and delivering on the current need for medicine to become more personalized.

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